Young filmmaker and scientist Victor Frankenstein (Charlie Tahan) lives with his parents, Edward and Susan Frankenstein (Martin Short and Catherine O'Hara) and his beloved dog, Sparky, in the quiet town of New Holland. Victor's intelligence is recognized by his classmates at school, his somber next-door neighbor, Elsa Van Helsing (Winona Ryder), mischievous, Igor-like Edgar "E" Gore (Atticus Shaffer), obese and gullible Bob (Robert Capron), overconfident Toshiaki (James Hiroyuki Liao), creepy Nassor (also Short), and an eccentric girl nicknamed Weird Girl (also O'Hara), but communicates little with them due to his relationship with his dog. Concerned with his son's isolation, Victor's father encourages him to take up baseball and make achievements outside of science. Victor hits a home run at his first game, but Sparky, pursuing the ball, is struck by a car and killed. Inspired by his science teacher Mr. Rzykruski's (Martin Landau) demonstration of the effect of electricity on dead frogs, a depressed Victor digs up Sparky's corpse, brings him to his makeshift laboratory in the attic, and successfully reanimates him with lightning. Seeing Weird Girl's living cat, Mr. Whiskers, the undead Sparky escapes from the attic and explores the neighborhood. He is recognized by Edgar, who blackmails Victor into teaching him how to raise the dead. The two reanimate a dead goldfish, which turns invisible due to an error with the experiment. Edgar brags about the undead fish to Toshiaki and Bob, which, in panic of losing the upcoming science fair, inspires them to make a rocket out of soda bottles, which causes Bob to break his arm and Mr. Rzykruski to be blamed and fired due to his accused influencing and reviling the townsfolk for questioning his methods when he steps up for self-defense. So, the gym teacher (also O'Hara) replaces Mr. Rzykruski.